Platelet and fibrin deposition on coronary stents in minipigs: effect of hirudin versus heparin.
Identifieur interne : 004C21 ( Main/Exploration ); précédent : 004C20; suivant : 004C22Platelet and fibrin deposition on coronary stents in minipigs: effect of hirudin versus heparin.
Auteurs : RBID : pubmed:7678021English descriptors
- KwdEn :
- Angioplasty, Balloon, Coronary, Animals, Aspirin (therapeutic use), Coronary Thrombosis (blood), Coronary Thrombosis (pathology), Coronary Thrombosis (prevention & control), Dextrans (therapeutic use), Drug Evaluation, Preclinical, Drug Therapy, Combination, Female, Fibrin (drug effects), Heparin (therapeutic use), Hirudin Therapy, Hirudins (analogs & derivatives), Indium Radioisotopes, Male, Platelet Aggregation (drug effects), Recombinant Proteins (therapeutic use), Stents, Swine, Swine, Miniature (blood), Time Factors.
- MESH :
- chemical , analogs & derivatives : Hirudins.
- chemical , drug effects : Fibrin.
- chemical , therapeutic use : Aspirin, Dextrans, Heparin, Recombinant Proteins.
- blood : Coronary Thrombosis, Swine, Miniature.
- drug effects : Platelet Aggregation.
- pathology : Coronary Thrombosis.
- prevention & control : Coronary Thrombosis.
- Angioplasty, Balloon, Coronary, Animals, Drug Evaluation, Preclinical, Drug Therapy, Combination, Female, Hirudin Therapy, Indium Radioisotopes, Male, Stents, Swine, Time Factors.
Abstract
The present study was designed to test the hypothesis that the direct thrombin hirudin is more efficient than heparin in reducing thrombus formation after coronary stenting.
PubMed: 7678021
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Platelet and fibrin deposition on coronary stents in minipigs: effect of hirudin versus heparin.</title><author><name sortKey="Buchwald, A B" uniqKey="Buchwald A">A B Buchwald</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, University Clinic, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, University Clinic, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Sandrock, D" uniqKey="Sandrock D">D Sandrock</name></author><author><name sortKey="Unterberg, C" uniqKey="Unterberg C">C Unterberg</name></author><author><name sortKey="Ebbecke, M" uniqKey="Ebbecke M">M Ebbecke</name></author><author><name sortKey="Nebendahl, K" uniqKey="Nebendahl K">K Nebendahl</name></author><author><name sortKey="L Ders, S" uniqKey="L Ders S">S Lüders</name></author><author><name sortKey="Munz, D L" uniqKey="Munz D">D L Munz</name></author><author><name sortKey="Wiegand, V" uniqKey="Wiegand V">V Wiegand</name></author></titleStmt><publicationStmt><date when="1993">1993</date><idno type="RBID">pubmed:7678021</idno><idno type="pmid">7678021</idno><idno type="wicri:Area/Main/Corpus">005135</idno><idno type="wicri:Area/Main/Curation">005135</idno><idno type="wicri:Area/Main/Exploration">004C21</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angioplasty, Balloon, Coronary</term><term>Animals</term><term>Aspirin (therapeutic use)</term><term>Coronary Thrombosis (blood)</term><term>Coronary Thrombosis (pathology)</term><term>Coronary Thrombosis (prevention & control)</term><term>Dextrans (therapeutic use)</term><term>Drug Evaluation, Preclinical</term><term>Drug Therapy, Combination</term><term>Female</term><term>Fibrin (drug effects)</term><term>Heparin (therapeutic use)</term><term>Hirudin Therapy</term><term>Hirudins (analogs & derivatives)</term><term>Indium Radioisotopes</term><term>Male</term><term>Platelet Aggregation (drug effects)</term><term>Recombinant Proteins (therapeutic use)</term><term>Stents</term><term>Swine</term><term>Swine, Miniature (blood)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Hirudins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Fibrin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Aspirin</term><term>Dextrans</term><term>Heparin</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronary Thrombosis</term><term>Swine, Miniature</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Platelet Aggregation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronary Thrombosis</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronary Thrombosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Angioplasty, Balloon, Coronary</term><term>Animals</term><term>Drug Evaluation, Preclinical</term><term>Drug Therapy, Combination</term><term>Female</term><term>Hirudin Therapy</term><term>Indium Radioisotopes</term><term>Male</term><term>Stents</term><term>Swine</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study was designed to test the hypothesis that the direct thrombin hirudin is more efficient than heparin in reducing thrombus formation after coronary stenting.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">7678021</PMID><DateCreated><Year>1993</Year><Month>01</Month><Day>27</Day></DateCreated><DateCompleted><Year>1993</Year><Month>01</Month><Day>27</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0735-1097</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>1993</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Journal of the American College of Cardiology</Title><ISOAbbreviation>J. Am. Coll. Cardiol.</ISOAbbreviation></Journal><ArticleTitle>Platelet and fibrin deposition on coronary stents in minipigs: effect of hirudin versus heparin.</ArticleTitle><Pagination><MedlinePgn>249-54</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The present study was designed to test the hypothesis that the direct thrombin hirudin is more efficient than heparin in reducing thrombus formation after coronary stenting.</AbstractText><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Despite aggressive anticoagulation, subacute thrombosis of coronary stents is a major complication associated with these new devices.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In 19 minipigs indium-111-labeled thrombocytes and iodine-125-labeled fibrinogen were injected 14 to 19 h before coronary implantation of tantalum balloon-expandable stents. In group 1 (n = 6, seven stents), a bolus of heparin (100 U/kg body weight) was given before stenting. Group 2 (n = 6, 11 stents) received both dextran (500 ml) and heparin (a 100-U/kg bolus followed by a continuous infusion of 50 U/kg per h). In group 3 (n = 7, 13 stents), hirudin (recombinant desulphatohirudin HV 1 [CGP 39393] [1 mg/kg]) was given before stent implantation, followed by an infusion of 1 mg/kg per h. All animals were pretreated with aspirin (250 mg intravenously).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Activated partial thromboplastin time was prolonged to > 1.8 times control values in groups 2 and 3. Histologic examination after perfusion fixation 12 h after stenting showed a variable extent of thrombus on all stents. Medial tear was observed in three stents in group 1, six stents in group 2 and six stents in group 3. The number of platelets on all stents averaged 116.2 (range 22 to 522) x 10(6) in group 1, 64.3 (range 11 to 169) x 10(6) in group 2 and 19.7 (range 9 to 38) x 10(6) in group 3 (p < 0.05 vs. group 1 and vs. group 2). The increase in platelet deposition, associated with medial tear in all groups, was lowest in the hirudin group. Similarly, fibrin deposition was lowest on stents in hirudin-treated animals.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Recombinant hirudin significantly reduces platelet and fibrin deposition on coronary stents compared with the reduction achieved with combined heparin, dextran and aspirin.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Buchwald</LastName><ForeName>A B</ForeName><Initials>AB</Initials><Affiliation>Department of Cardiology, University Clinic, Göttingen, Germany.</Affiliation></Author><Author ValidYN="Y"><LastName>Sandrock</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Unterberg</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Ebbecke</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nebendahl</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Lüders</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Munz</LastName><ForeName>D L</ForeName><Initials>DL</Initials></Author><Author ValidYN="Y"><LastName>Wiegand</LastName><ForeName>V</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>J Am Coll Cardiol</MedlineTA><NlmUniqueID>8301365</NlmUniqueID><ISSNLinking>0735-1097</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Hirudins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>120993-53-5</RegistryNumber><NameOfSubstance>desirudin</NameOfSubstance></Chemical><Chemical><RegistryNumber>9001-31-4</RegistryNumber><NameOfSubstance>Fibrin</NameOfSubstance></Chemical><Chemical><RegistryNumber>9005-49-6</RegistryNumber><NameOfSubstance>Heparin</NameOfSubstance></Chemical><Chemical><RegistryNumber>K3R6ZDH4DU</RegistryNumber><NameOfSubstance>Dextrans</NameOfSubstance></Chemical><Chemical><RegistryNumber>R16CO5Y76E</RegistryNumber><NameOfSubstance>Aspirin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Angioplasty, Balloon, Coronary</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aspirin</DescriptorName><QualifierName MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Coronary Thrombosis</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Dextrans</DescriptorName><QualifierName MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Drug Evaluation, Preclinical</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Fibrin</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Heparin</DescriptorName><QualifierName MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Hirudin Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Hirudins</DescriptorName><QualifierName MajorTopicYN="Y">analogs & derivatives</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Platelet Aggregation</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Stents</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Swine, Miniature</DescriptorName><QualifierName MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7678021</ArticleId><ArticleId IdType="pii">0735-1097(93)90744-L</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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